Evidence map›Paper›PMID 42383912›Full record

ReviewSexually transmitted diseases2026

A New Era in Treponema pallidum Cultivation: Current Advances and Future Directions.

Kelly L Hawley, Linda Grillová, Lorenzo Giacani, Steven J Norris

Abstract readReview
In one paragraph

Review in Sexually transmitted diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kelly L HawleyFrom the Departments of Pediatrics, Medicine, and Immunology, UConn Health, Farmington, CT.
Linda GrillováParasites and Microbes Programme, Wellcome Sanger Institute, Hinxton, UK.
Lorenzo GiacaniDepartment of Medicine, University of Washington, Seattle, WA.
Steven J NorrisDepartment of Pathology & Laboratory Medicine, University of Texas Health Science Center at Houston - McGovern Medical School, Houston, TX.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although long-term in vitro cultivation of the syphilis agent, Treponema pallidum subspecies pallidum, was introduced less than a decade ago, it has revolutionized and accelerated research with this difficult pathogen. Moreover, it is allowing for the exploration of topics that could not easily be pursued when propagation in the rabbit model was the only possible method for the expansion of treponemes. This report, based on talks presented at the Shanghai International Syphilis Symposium 2025, provides an overview of how in vitro cultivation is currently being applied to syphilis research.

Indexed as

Bacteriological TechniquesSyphilisTreponema pallidumAnimalsHumansRabbits

Identifiers

PMID42383912
PMCPMC13326933

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.