ArticleSexually transmitted diseases2026
Advancements in Syphilis Vaccine Development.
Article in Sexually transmitted diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Looking Down the Road: Development of a Future Syphilis Vaccine.Sexually transmitted diseases · 2026Article
- Overview of the Shanghai International Syphilis Symposium (SISS 2025).Sexually transmitted diseases · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
In the last decade, we have witnessed outstanding scientific advances towards the development of a globally efficacious syphilis vaccine. This manuscript summarizes information presented at the Shanghai International Syphilis Symposium (October 20-22, 2025, Shanghai, China) during the Vaccine Development session. Dr. Lorenzo Giacani (University of Washington) moderated the session. Dr. Justin Radolf (UConn Health) summarized key historical research findings that inform modern vaccine development, emphasizing how protective immunity was demonstrated in the early days of syphilis vaccine research and attributed to antibodies. Drs. Caroline Cameron (University of Victoria), Melissa Caimano (UConn Health), and Feijun Zhao (University of South China) discussed their research relating to antigen selection, identification of potentially protective B cell epitopes, results of immunization/challenge experiments, vaccine delivery platforms, and manufacturing requirements, with particular emphasis on the development of chimeric vaccine candidates. While challenges remain, the application of high-throughput immunological, proteomic, and genomic techniques discussed here has revealed surface-exposed epitopes of TPA outer membrane proteins with promising, but as yet unproven, vaccine potential. Multiple vaccine designs have emerged as options to efficiently and effectively package these epitopes in chimeric structures and platforms that can meet manufacturing standards and requirements. Efforts are also ongoing to identify and procure clinically approved adjuvants to be delivered alongside vaccine candidates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.