Evidence map›Paper›PMID 42383908›Full record

ArticleSexually transmitted diseases2026

Innovations and Challenges in Syphilis Screening and Prevention Among Men Who Have Sex With Men: A Scoping Review.

Mariam Assi, Kimberly A Workowski, Leandro A Mena

Abstract readScoping Review
In one paragraph

Article in Sexually transmitted diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mariam AssiFrom the Division of Infectious Diseases, Department of Medicine, Emory University, Atlanta, GA.
Kimberly A Workowski
Leandro A Mena

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Syphilis rates among men who have sex with men have risen sharply worldwide, reflecting evolving sexual networks, persistent gaps in screening and care, and behavioral changes that have accompanied the broader uptake of HIV preexposure prophylaxis. At the same time, a new generation of biomedical tools, such as doxycycline postexposure prophylaxis and rapid point-of-care diagnostics, are reshaping prevention. However, implementation has been inconsistent across programs and jurisdictions, and important challenges remain in access, effectiveness, and sustainability. This narrative review synthesizes current evidence on innovative syphilis screening and prevention strategies among men who have sex with men, highlighting both promising interventions and critical limitations. We emphasize doxycycline postexposure prophylaxis, point-of-care testing, self-testing, and digital health innovations for their potential to extend reach to underserved populations and address structural barriers to care and argue that durable control of the epidemic will require equity-focused, multidisciplinary strategies integrating clinical, public health, and community-based efforts.

Indexed as

Homosexuality, MaleMass ScreeningSyphilisDigital HealthDoxycyclineHIV InfectionsHumansMalePoint-of-Care TestingSexual and Gender MinoritiesDoxycycline

Identifiers

PMID42383908
PMCPMC13326930

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.