Evidence map›Paper›PMID 42383903›Full record

ArticleSexually transmitted diseases2026

Congenital Syphilis Elimination in Latin America: A Systematic Analysis of Policy and Progress.

Angelica E Miranda, Jodie A Dionne, Bernardo Nuche-Berenguer, Leandro Sereno, Mónica Alonso Gonzalez, Lori Newman

Abstract read
In one paragraph

Article in Sexually transmitted diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Angelica E MirandaFrom the Department of Social Medicine, Universidade Federal do Espírito Santo, Espirito Santo, Brazil.
Jodie A DionneDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL.
Bernardo Nuche-BerenguerUnit of HIV, Hepatitis, Tuberculosis, Sexually Transmitted Infections and Malaria, Pan American Health Organizationand.
Leandro SerenoUnit of HIV, Hepatitis, Tuberculosis, Sexually Transmitted Infections and Malaria, Pan American Health Organizationand.
Mónica Alonso GonzalezUnit of HIV, Hepatitis, Tuberculosis, Sexually Transmitted Infections and Malaria, Pan American Health Organizationand.
Lori NewmanDepartment for STI and Gynecology in the Women's Health Innovations Team of the Bill and Melinda Gates Foundation.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSyphilis in pregnancy and congenital syphilis (CS) remain major public health challenges in Latin America despite long-standing elimination initiatives. CS incidence continues to rise, although diagnosis and treatment are available, reflecting persistent programmatic gaps. A systematic assessment of strengths, weaknesses, opportunities, and threats (SWOT) can help refine strategies and accelerate progress toward the elimination of mother-to-child transmission (EMTCT) of syphilis.

methodsWe performed a qualitative SWOT analysis of public health policies addressing syphilis in pregnancy and CS in Latin American countries. Data sources included Pan-American Health Organization databases, global monitoring databases, national data, peer-reviewed literature, and programmatic reports. Evidence was synthesized using a standardized matrix to classify internal and external factors affecting syphilis control.

resultsRegional strengths include political commitment, national guidelines aligned with Pan-American Health Organization/World Health Organization recommendations, high antenatal care coverage, use of rapid and HIV/syphilis tests, and established surveillance systems. Key weaknesses include late antenatal care initiation, gaps in timely testing and treatment, regulatory barriers to point-of-care testing and penicillin administration, benzathine penicillin shortages, data quality limitations, fragmented governance and care, and weak partner management. Opportunities include strengthening the EMTCT agenda via program integration, digital health expansion, regional collaboration, and innovative diagnostic strategies. Threats include rising syphilis incidence, competing public health emergencies, political and economic instability, poverty, exclusion and stigma, and loss-to-follow-up during and after pregnancy due to population mobility.

conclusionsDespite political commitment, Latin America remains far from achieving EMTCT of syphilis. Strengthening integrated services, supply chains, data systems, and partner management is needed to improve outcomes.

Indexed as

Disease EradicationHealth PolicyInfectious Disease Transmission, VerticalPregnancy Complications, InfectiousSyphilisSyphilis, CongenitalFemaleHumansLatin AmericaPan American Health OrganizationPregnancyPrenatal CarePublic Health

Identifiers

PMID42383903
PMCPMC13326914

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.