ArticleJournal of virology2026
Periodic genome sequences facilitate packaging in a single-stranded DNA virus.
Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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0 citing papers in PubMed.
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Authors and funding
4 authors.
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Abstract
Icosahedral viruses organize and compact their genomes within volumetrically constrained capsids. Double-stranded (ds) DNA viral genomes form ordered spool-like structures when packaged into preformed capsids. By contrast, single-stranded (ss) RNA viral coat proteins recognize genomic sequences or structures, nucleating assembly around folded genomes. A similar mechanism may occur in some ssDNA systems; however, in parvo- and microviruses, the ss genome is concurrently synthesized and packaged into a preformed shell. In the øX174 X-ray virion structure, only ~12% of the genome is ordered. Consequently, the mechanism by which the genome is accommodated within the constrained capsid remains obscure. Sequence motifs within the øX174 genome produce a periodic segmentation pattern consistent with T = 1 icosahedral symmetry. To determine the function of these motifs, a subset within the first five packaged segments was altered. No regulatory elements or encoded amino acids were changed. The resulting mutant, øX
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