Evidence map›Paper›PMID 42383764›Full record

ArticleMicrobiology spectrum2026

Tail-specific protease (Tsp)-mediated envelope remodeling and beta-lactam tolerance in

Jenet Narzary, Sayed Golam Mohiuddin, Aslan Massahi, Mehmet A Orman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jenet NarzaryDepartment of Chemical and Biomolecular Engineering, University of Houston, Houston, Texas, USA.ORCID 0009-0009-5101-8044
Sayed Golam MohiuddinDepartment of Chemical and Biomolecular Engineering, University of Houston, Houston, Texas, USA.ORCID 0000-0001-7613-6324
Aslan MassahiDepartment of Chemical and Biomolecular Engineering, University of Houston, Houston, Texas, USA.
Mehmet A OrmanDepartment of Chemical and Biomolecular Engineering, University of Houston, Houston, Texas, USA.ORCID 0000-0001-8499-9154

Funding

Characterizing a Self-Digesting-Mediated Reversible Drug Tolerance Mechanism in BacteriaR01AI143643 · NIAID · UNIVERSITY OF HOUSTON · PI ORMAN, MEHMET A. · 2020 to 2024
$1.9M
National Institute of Allergy and Infectious Diseases R01-AI143643National Science Foundation 2326142National Science Foundation CAREER 2044375NIAID NIH HHS R01 AI143643
6 · The paper itself

Abstract

Bacterial persisters are transiently drug-tolerant cells that survive antibiotic treatment without genetic resistance. While certain cytosolic proteases are known to regulate persistence through toxin-antitoxin and stress pathways, the role of envelope-associated proteolysis remains poorly understood. Here, our high-throughput promoter-reporter screen identified several candidate proteases, and subsequent antibiotic treatment of knockout strains lacking these degradative genes revealed that Tsp plays a critical role in beta-lactam persistence. The deletion of

Indexed as

Anti-Bacterial Agentsbeta-LactamsCell WallEndopeptidasesEscherichia coliEscherichia coli Proteinsbeta Lactam AntibioticsCell MembraneMicrobial Sensitivity TestsProteolysisAnti-Bacterial Agentsbeta Lactam Antibioticsbeta-LactamsEndopeptidasesEscherichia coli Proteinsbacterial persistersbeta-lactam antibioticscell envelope-associated proteinsEscherichia coliTsp protease

Identifiers

PMID42383764
PMCPMC13435647

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.