Evidence map›Paper›PMID 42383753›Full record

ReviewmBio2026

mGem: Subcellular compartments in bacterial pathogens and their role during infection.

Christopher J Corcoran, Eric P Skaar

Abstract readReview
In one paragraph

Review in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Christopher J CorcoranDepartment of Pathology, Microbiology, and Immunology, Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0001-8796-2883
Eric P SkaarDepartment of Pathology, Microbiology, and Immunology, Vanderbilt Institute for Infection, Immunology, and Inflammation, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0001-5094-8105

Funding

Host-mediated zinc sequestration during Acinetobacter baumannii infectionR01AI101171 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI WALTER J. CHAZIN, DAVID P. GIEDROC · 2013 to 2026
$8.2M
Vanderbilt Antibody and Antigen Discovery for Clostridioides difficile VaccinesU19AI174999 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Dana Borden Lacy · 2023 to 2026
$7.9M
Pathobiology of heme inducible transporters in Gram positive pathogensR01AI073843 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SKAAR, ERIC P · 2009 to 2025
$5.9M
Molecular mapping of microbial communities at the host-pathogen interface by multi-modal 3-dimensional imaging mass spectrometryR01AI138581 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Eric P Skaar, Jeffrey M Spraggins · 2018 to 2026
$5.2M
Childhood Infections Research ProgramT32AI095202 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI JAMES E CASSAT · 2011 to 2026
$4.2M
Nutritional immunity and microbial competition during Clostridioides difficile infectionR01AI164587 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SKAAR, ERIC P · 2022 to 2025
$2.4M
The role of the ZNG1 metallochaperone in the host response to infectionR01AI178929 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DAVID P. GIEDROC, Eric P Skaar · 2023 to 2026
$2.2M
National Institute of Allergy and Infectious Diseases R01AI73843, R01AI138581, R01AI101171, R01AI164587, R01AI178929, U19AI174999National Institute of Allergy and Infectious Diseases T32AI095202NIAID NIH HHS R01 AI073843NIAID NIH HHS R01 AI101171NIAID NIH HHS R01 AI138581NIAID NIH HHS R01 AI164587NIAID NIH HHS R01 AI178929NIAID NIH HHS T32 AI095202NIAID NIH HHS U19 AI174999
6 · The paper itself

Abstract

Bacterial subcellular compartments and organelles allow for the spatial organization and sequestration of metabolic pathways, toxic intermediates, and key nutrients. The prevalence of these compartments across bacterial phyla, including in prominent human pathogens, has become increasingly defined in the literature. However, the functions of subcellular compartments in bacterial pathogens and their contributions to virulence remain understudied, leaving many questions unanswered. In this review, we summarize current findings regarding the prevalence of proteinaceous and membrane-bound compartments in pathogenic bacterial species and their role during infection, and we highlight important aspects where new discoveries could have the greatest impact. Further insight into the function of these subcellular structures may reveal novel targets for antimicrobial development against the increasing threat of multi-drug-resistant pathogens.

Indexed as

BacteriaBacterial InfectionsOrganellesBacterial ProteinsHost-Pathogen InteractionsHumansVirulenceBacterial Proteinsbacterial microcompartmentbacterial pathogenesisencapsulinferrosomesubcellular compartments

Identifiers

PMID42383753
PMCPMC13463818

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.