Evidence map›Paper›PMID 42383739›Full record

ArticleJournal of virology2026

ATG9A is an essential host factor for parechovirus RNA replication.

You Li, Lorellin A Durnell-Bettis, Fahmida Alam, Adriana E Golding, Juan S Bonifacino, Matthew R Vogt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

You LiDepartment of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0001-5458-6009
Lorellin A Durnell-BettisDepartment of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Fahmida AlamDepartment of Microbiology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Adriana E GoldingDivision of Neuroscience and Cellular Structure, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
Juan S BonifacinoDivision of Neuroscience and Cellular Structure, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA.
Matthew R VogtDepartment of Pediatrics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0002-4204-5827

Funding

Protein Trafficking In The Endosomal-Lysosomal SystemZIAHD001607 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI BONIFACINO, JUAN · 2009 to 2025
$48.3M
Preclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mark D Shen · 2020 to 2026
$9.7M
Human antibody modification of enterovirus D68 infectionK08AI156125 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI VOGT, MATTHEW R · 2021 to 2025
$900k
Eunice Kennedy Shriver National Institute of Child Health and Human Development ZIA HD001607, P50 HD103573Intramural NIH HHS ZIA HD001607NIAID NIH HHS K08 AI156125NICHD NIH HHS P50 HD103573
6 · The paper itself

Abstract

Parechoviruses (PeVs) are single-stranded, positive-sense RNA viruses in the IMPORTANCE: Parechovirus (PeV) is a widespread but understudied human pathogen capable of causing severe neurologic disease and sepsis in neonates and infants. Through a CRISPR-based screen, we identified key host factors required for PeV-A3 infection and uncovered a novel, critical role of ATG9A in viral RNA replication that is independent of canonical autophagy. These findings provide new insight into the molecular pathogenesis of the virus and establish a foundation for future antiviral therapeutic development.

Indexed as

Autophagy-Related ProteinsMembrane ProteinsParechovirusPicornaviridae InfectionsRNA ReplicationRNA, ViralVesicular Transport ProteinsVirus ReplicationAutophagyCell LineHost-Pathogen InteractionsHumansATG9A protein, humanAutophagy-Related ProteinsMembrane ProteinsRNA, ViralVesicular Transport ProteinsATG2ATG9AautophagyGolgiparechoviruspicornavirus

Identifiers

PMID42383739
PMCPMC13386875

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.