Observational studyJournal of pediatric gastroenterology and nutrition2026
Cognitive assessment in children with intestinal failure on and weaned off parenteral nutrition.
Observational study in Journal of pediatric gastroenterology and nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The trial behind it
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Who cites it
1 citing paper in PubMed.
- Cognitive assessment in children with intestinal failure on and weaned off parenteral nutrition.Journal of pediatric gastroenterology and nutrition · 2026Observational
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
objectivesChildren with intestinal failure (IF) are vulnerable to adverse cognitive outcomes. We assessed intelligence quotient (IQ) and identified associated factors.
methodsMulticentre international cross-sectional study in children with IF and weaned children, treated at Erasmus MC Sophia Children's Hospital, Amsterdam UMC Emma Children's Hospital (both The Netherlands) and Birmingham Women's and Children's NHS Foundation Trust (UK). Primary outcomes were IQ outcomes using Wechsler's preschool and primary scale of intelligence (WPPSI-III), Wechsler intelligence scale for children (WISC-V) or Wechsler adult intelligence scale (WAIS-IV). Secondary outcomes were cognitive development outcomes, the correlation between IQ and possible related factors, and the linear relationship between the most influential factors and IQ outcomes using multiple linear regression.
resultsFifty children were included: 50% boys; median age 9.1 (IQR 6.5-12.5) years; gestational age 34 (30-37) weeks; birth weight 2135 (1279-2545) grams; most common underlying condition was necrotising enterocolitis (28%); 21/50 children (42%) received home parenteral nutrition (PN), median PN-duration was 26.8 (7.5-66.5) months. Median IQ score was 92.0 (74.3-101.0), 15 children (30%) had very/extremely low IQ, both significantly different from the normal population (p < 0.001). Parental occupational and educational levels, number of line infections, and total hospital admission duration showed the strongest correlations with IQ outcomes, with line infections remaining significant after correction for multiple analyses (rho -0.52, p < 0.01). However, none were significant after multiple linear regression.
conclusionsChildren with IF generally exhibit an average IQ but are at risk to have a below-average IQ. While separate factors were correlated with IQ outcomes, none remained significant after multiple linear regression.
trial registrationClinicalTrials.gov identifier: MEC 2019-098, NL-OMON54827, https://trialsearch.who.int/Trial2.aspx?TrialID=NL-OMON54827.
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