ArticleACS infectious diseases2026
Coumarin-Mediated Inhibition of Diadenylate Cyclase Correlates with Impaired Biofilm Formation in
Edwin M Rojas, Abhishek Govindan, Parvathy Babu, Soniya Joseph, Hua Zhang, Yanting Zhu, Tyrese Boddie, Hui-Ting Lee, Hui Wu, Sadanandan E Velu
Abstract read
In one paragraphArticle in ACS infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Edwin M RojasDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.
Abhishek GovindanDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.
Parvathy BabuDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.
Soniya JosephDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.
Hua ZhangDepartment of Biomaterial and Biomedical Sciences, School of Dentistry, Oregon Health & Science University, Portland, Oregon 97239, United States.
Yanting ZhuDepartment of Biomaterial and Biomedical Sciences, School of Dentistry, Oregon Health & Science University, Portland, Oregon 97239, United States.
Tyrese BoddieDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.ORCID 0009-0008-7977-2295 Hui-Ting LeeDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.ORCID 0000-0002-2648-4053 Hui WuDepartment of Biomaterial and Biomedical Sciences, School of Dentistry, Oregon Health & Science University, Portland, Oregon 97239, United States.ORCID 0000-0003-1694-3954 Sadanandan E VeluDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, Alabama 35294, United States.ORCID 0000-0002-0342-2378 Funding
SMALL MOLECULE INHIBITORS OF CARIOGENIC BIOFILMSR01DE022350 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Christian Corey Melander, Hui Wu · 2012 to 2026
$4.3MBACTERIAL SECOND MESSENGER MEDIATED VIRULENCE REGULATION IN STREPTOCOCCUS MUTANSR01DE028329 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WU, HUI · 2019 to 2023
$1.7MMicrobial Biofilms as Regulators of Amphetamine Use DisordersR21DA059844 · NIDA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CARTER, ANGELA MICHELLE, VELU, SADANANDAN E. · 2024 to 2025
$408kHydrogel encapsulated biofilm inhibitors for dental caries prevention and treatmentR21DE028349 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI VELU, SADANANDAN E. · 2019 to 2020
$396kStreptococcus mutans diadenylate cyclase: A promising target for preventing dental cariesF30DE030334 · NIDCR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ROJAS, EDWIN M · 2020 to 2024
$212kNIDA NIH HHS R21 DA059844NIDCR NIH HHS F30 DE030334NIDCR NIH HHS R01 DE022350NIDCR NIH HHS R01 DE028329NIDCR NIH HHS R21 DE028349
6 · The paper itselfAbstract
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Indexed as
Anti-Bacterial AgentsBacterial ProteinsBiofilmsCoumarinsEnzyme InhibitorsPhosphorus-Oxygen LyasesStreptococcus mutansStructure-Activity RelationshipAnti-Bacterial AgentsBacterial ProteinscoumarinCoumarinsEnzyme InhibitorsPhosphorus-Oxygen Lyasesbiofilmc-di-AMPcoumarindiadenylate cyclaseinhibitorS. mutans
Identifiers
PMID42383450
PMCPMC13366584
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