Evidence map›Paper›PMID 42383298›Full record

Trial reportClinical transplantation2026

Randomized Controlled Trial of a Digital Intervention (KidneyTIME) to Promote Live Donor Kidney Transplantation.

Liise K Kayler, Naoru Koizumi, Jing Nie, Maria Keller, Renee B Cadzow, Katia Noyes, Jon Von Visger, Heather Gardiner, Thomas H Feeley

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Liise K KaylerDepartment of Surgery, Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, State University of New York, Buffalo, New York, USA.
Naoru KoizumiSchar School of Policy and Government, George Mason University, Fairfax, Virginia, USA.
Jing NieDepartment of Epidemiology and Environmental Health, School of Public Health & Health Professions, University at Buffalo, State University of New York, Buffalo, New York, USA.
Maria KellerDepartment of Surgery, Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, State University of New York, Buffalo, New York, USA.
Renee B CadzowDepartment of Epidemiology and Environmental Health, School of Public Health & Health Professions, University at Buffalo, State University of New York, Buffalo, New York, USA.
Katia NoyesDepartment of Epidemiology and Environmental Health, School of Public Health & Health Professions, University at Buffalo, State University of New York, Buffalo, New York, USA.
Jon Von VisgerTransplant and Kidney Care Regional Center of Excellence, Erie County Medical Center, Buffalo, New York, USA.
Heather GardinerDepartment of Surgery, Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, State University of New York, Buffalo, New York, USA.
Thomas H FeeleyDepartment of Communication, University at Buffalo, State University of New York, Buffalo, New York, USA.

Funding

Increasing Live Donor Kidney Transplantation Through Video-based Education and Mobile CommunicationR01DK129845 · NIDDK · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI FEELEY, THOMAS, KAYLER, LIISE · 2021 to 2024
$2.6M
NIH HHS R01DK129845
6 · The paper itself

Abstract

backgroundDigital behavioral interventions are promising to support patients' pursuit of live donor kidney transplantation (LDKT). This study examined the effectiveness of a patient-led digital intervention (KidneyTIME) versus active control on facilitating LDKT.

methodsAn individually randomized (1:1) parallel-group trial was conducted at a safety-net hospital transplant program with adult kidney transplant candidates in referral, evaluation, or listed phases who were English-speaking and had email or text access. KidneyTIME participants received animated video LDKT education and outreach enablement via video sharing. The primary outcome was ≥1 live donor inquiry within 12 months in the intent-to-treat population. Secondary outcomes included LDKT knowledge, attitudes, behaviors toward listing and donor outreach, extent of video sharing, and intervention acceptability assessed by survey at 4 timepoints post-exposure.

resultsBetween 4/22 and 7/23, 422 candidates (mean age 54 years; 57% male, 45% income < $30,000) were randomized to KidneyTIME (n = 212) or active control (n = 210). Between-group differences in donor outreach behaviors and receipt of a donor inquiry were not detected. KidneyTIME participants had higher LDKT knowledge (p = 0.002), new listing behaviors (IRR:1.62, p = 0.005), and extent of video sharing (p = 0.016). In planned as-treated analysis, intervention participants who viewed at least one optional video had significantly higher cumulative donor inquiry probability than those who did not (viewer 22.9%; non-viewer 9.8%, p = 0.029). Intervention acceptability scores were high.

conclusionA digital intervention self-administered by patients did not increase donor inquiries. Preliminary dose effect findings suggest the need to consider how to encourage people to engage more with the intervention.

Indexed as

Health Knowledge, Attitudes, PracticeKidney Failure, ChronicKidney TransplantationLiving DonorsPatient Education as TopicTissue and Organ ProcurementAdherence InterventionsAdultDigital MediaFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisanimated videodigital interventioneducationhealth communicationlive donor kidney transplantationmultimediavisual learning

Identifiers

PMID42383298
PMCPMC13320723

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.