ReviewWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
Ischial Pressure Ulcer Reconstruction: A Critical Review of the Paradigm Shift From Wound Coverage to Functional Restoration.
Review in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
Abstract
Ischial pressure ulcers (IPUs), severe complications in patients with prolonged immobility, are challenging due to high recurrence. Moving beyond anatomical closure, the field now prioritises functional-integrated reconstruction. This paradigm emphasises radical debridement and the transfer of well-vascularized perforator flaps to obliterate dead space, cover wounds, and restore protective sensation, aiming to break the recurrence cycle and restore patient autonomy. This review critically synthesises contemporary advances driving this shift. It details the development of precision and minimally invasive perforator flap techniques, including sensory nerve coaptation and chimeric designs. The integration of multimodal perioperative strategies, such as antibiotic-loaded bone cement and fluorescence angiography, is discussed. The adjunctive role of traditional Chinese medicine and the exploratory potential of regenerative approaches (stem cells, 3D-bioprinting) are considered. Finally, practical recommendations for implementing this holistic approach are provided, along with a clinical flowchart to guide staged management. By consolidating these advances, this review provides a framework to transition IPU management from simple wound healing towards comprehensive functional and social rehabilitation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.