ArticleOsteoarthritis and cartilage open2026
Frequency and factors associated with neuropathic pain in patients with knee osteoarthritis.
Article in Osteoarthritis and cartilage open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To determine the frequency and factors associated with neuropathic pain in patients with knee osteoarthritis seen during rheumatology consultations. Methods: This was a descriptive and analytical cross-sectional study of patients with knee osteoarthritis who met the ACR criteria and who were seen in rheumatology consultations at a referral university hospital. A DN4 score greater than or equal to 4 was used to classify the pain as like neuropathic. Multivariable logistic regression analysis was used to determine adjusted ORs and 95% CI. Results: Three hundred and twenty-five patients with knee osteoarthritis were included in the study. The mean age of the patients was 57.85 ± 11.89 years. Neuropathic-like pain (DN4 ≥4) was identified in 32% of participants. Among DN4-positive individuals, the mean DN4 score was 6.51 ± 1.60 (range 4-10). The mean global WOMAC score was 30.98 ± 10.98. The mean score for pain under load according to the visual analog scale was 3.35 ± 1.376. After multivariable analysis, the associated factors with neuropathic-like pain were a history of knee trauma (OR = 4.525; 95%CI [1.497-13.678]; p = 0.007). Psychological history (OR = 9.941; 95%CI [3.066-32.235]; p < 0.001). Kellgren-Lawrence grades 3 and 4 (OR = 7.599; 95%CI [2.372-24.432]; p = 0.001) and WOMAC global score (OR = 1.093; 95%CI [1.053-1.134]; p < 0.001). Conclusion: A significant proportion of patients suffering from osteoarthritis of the knee experienced neuropathic-like pain, requiring the implementation of prevention and treatment strategies.
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