ArticleACG case reports journal2026
Anti-Hu-Associated Paraneoplastic Myeloneuropathy as the Initial Presentation of Early-Onset Colon Adenocarcinoma.
Article in ACG case reports journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Anti-Hu paraneoplastic neurological syndromes are most commonly associated with small-cell lung cancer and are rarely reported in colorectal malignancy. A 43-year-old man presented with progressive sensory neuropathy and weight loss. Evaluation revealed positive serum anti-Hu antibodies, markedly elevated cerebrospinal fluid protein, and imaging demonstrating an ascending colon mass. Right hemicolectomy confirmed Stage IIIA (pT3N1aM0) moderately differentiated adenocarcinoma, with mismatch repair-deficient (loss of MLH1 and PMS2) and B-Raf proto-oncogene, serine/threonine kinase wild-type tumor profile. Despite a significant family history, the patient had not undergone recommended early colorectal screening. Postoperative circulating tumor DNA was negative, and the patient was placed on active surveillance; however, neurological symptoms persisted, and immunomodulatory therapy access was initially limited. This case highlights a rare association between anti-Hu-associated myeloneuropathy and early-onset colon cancer and underscores the importance of malignancy evaluation in unexplained sensory neuronopathy.
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