Evidence map›Paper›PMID 42383203›Full record

ArticleBioactive materials2026

3D matrix stiffness drives energy metabolism to orchestrate stem cell osteogenesis via microtubule acetylation and mitochondrial dynamics.

Zhijie Yang, Jing Na, Yu Liu, Gan Yue, Fei Song, Chiyu Li, Qiusheng Shi, Yubo Fan, Lisha Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhijie YangKey Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education; School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China.
Jing NaKey Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education; School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China.
Yu LiuKey Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education; School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China.
Gan YueKey Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education; School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China.
Fei SongKey Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education; School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China.
Chiyu LiKey Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education; School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China.
Qiusheng ShiKey Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education; School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China.
Yubo FanKey Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education; School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China.
Lisha ZhengKey Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education; School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydrogels are widely recognized as promising materials for bone regeneration. However, how their biophysical properties, particularly stiffness, affect stem cell behavior in three-dimensional (3D) environments remains poorly understood. It is also unclear whether energy metabolism and mitochondrial dynamics play a role in mediating stiffness-regulated stem cell differentiation. Our study demonstrates that a soft extracellular matrix (ECM) enhances cytoskeletal polymerization and cell elongation. In vitro, a soft ECM promoted osteogenic differentiation, while

Indexed as

3DEnergy metabolismMicrotubule acetylationMitochondria dynamicsOsteogenesisStiffness

Identifiers

PMID42383203
PMCPMC13316091

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.