Core-shell commensal biocapsules for

Lily Foley, Sonika Kohli, Shuchang Tian, Logan C Eisaman, Harshita Ganga, Gabrielle Hamner, Matthew R Aronson, Jordan E Bisanz, Scott H Medina

Abstract read

PubMed Full text at PMC Publisher

In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lily FoleyDepartment of Biomedical Engineering, Penn State University, University Park, PA, 16802, USA.

Sonika KohliDepartment of Biomedical Engineering, Penn State University, University Park, PA, 16802, USA.

Shuchang TianDepartment of Biochemistry and Molecular Biology, Penn State University, University Park, PA, 16802, USA.

Logan C EisamanDepartment of Biomedical Engineering, Penn State University, University Park, PA, 16802, USA.

Harshita GangaDepartment of Biomedical Engineering, Penn State University, University Park, PA, 16802, USA.

Gabrielle HamnerDepartment of Biomedical Engineering, Penn State University, University Park, PA, 16802, USA.

Matthew R AronsonDepartment of Biomedical Engineering, Penn State University, University Park, PA, 16802, USA.

Jordan E BisanzDepartment of Biochemistry and Molecular Biology, Penn State University, University Park, PA, 16802, USA.

Scott H MedinaDepartment of Biomedical Engineering, Penn State University, University Park, PA, 16802, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the profound influence that gut microbiome composition has on human health, the development of live microbe treatments is constrained by a lack of knowledge on single-species functions within the gastrointestinal (GI) tract. A key barrier is the absence of broadly accessible tools capable of overcoming colonization resistance and enabling spatiotemporal control of microbiome ecology. To address this gap, we have developed a core-shell capsular material, termed a biocapsule, designed to promote the engraftment of a defined bacterial payload to a modified GI niche, thereby enabling precision engineering of commensal populations

Identifiers

PMID42383199

DOI10.1016/j.bioactmat.2026.05.014

PMCPMC13315643

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LicenceCC BY-NC-ND

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.