ArticleNature. Mental health2023
Lesion network localization of depression in multiple sclerosis.
Article in Nature. Mental health, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed.
- Sex Differences in the Neuropsychiatric Symptoms of Multiple Sclerosis: Symptômes neuropsychiatriques de la sclérose en plaques: différences selon le sexe.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2026Article
- The dynamics of AMPA receptors underlies the efficacy of ketamine in treatment resistant patients with depression.Molecular psychiatry · 2026Article
- Mapping the functional connectome between grey matter and white matter.Communications biology · 2026Article
- Depression as a Disease of White Matter Network Disruption: Learning From Multiple Sclerosis.Biological psychiatry · 2026Review
- Investigating the methodological foundation of lesion network mapping.Nature neuroscience · 2026Article
- Monoaminergic Networks of Cognitive and Behavioral Symptoms in Early Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Network Localization of Fatigue in Multiple Sclerosis.Annals of clinical and translational neurology · 2026Article
- Lesion Location and Functional Connections Reveal Cognitive Impairment Networks in Multiple Sclerosis.Annals of clinical and translational neurology · 2026Article
- Integrating direct electrical stimulation with brain connectivity predicts lesion-induced language impairment and recovery.Communications medicine · 2025Article
- Understanding Depression in People Living with Multiple Sclerosis: A Narrative Review of Recent Literature.Neurology and therapy · 2025Review
- Investigating mood and cognition in people with multiple sclerosis: a prospective cross-sectional study protocol.BMJ open · 2025Article
- Convergent mapping of a tremor treatment network.Nature communications · 2025Article
- Uncinate Fasciculus Lesion Burden and Anxiety in Multiple Sclerosis.JAMA network open · 2025Article
- Enhancing cognitive performance prediction by white matter hyperintensity connectivity assessment.Brain : a journal of neurology · 2024Article
- White matter engagement in brain networks assessed by integration of functional and structural connectivity.NeuroImage · 2024Article
- Evidence of symptom specificity for depression in multiple sclerosis: A two sample Mendelian randomization study.Multiple sclerosis and related disorders · 2024Article
- A potential target for noninvasive neuromodulation of PTSD symptoms derived from focal brain lesions in veterans.Nature neuroscience · 2024Article
- Association of Anxiety with Uncinate Fasciculus Lesion Burden in Multiple Sclerosis.medRxiv : the preprint server for health sciences · 2024Article
- Investigating Mood and Cognition in People with Multiple Sclerosis: A Prospective Study Protocol.medRxiv : the preprint server for health sciences · 2024Article
- The interplay between polygenic score for tumor necrosis factor-α, brain structural connectivity, and processing speed in major depression.Molecular psychiatry · 2024Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Depression is a common debilitating complication of multiple sclerosis (MS), but the role of lesion location remains unclear. Recent work shows that stroke lesions and therapeutic neuromodulation sites that modify depression are connected to a common brain circuit, providing an
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.