ArticleClinical and translational radiation oncology2026
Radiotherapy quality assurance in the PRO-GLIO trial: results from a dummy run comparing experts across twelve institutions in two Scandinavian countries.
Article in Clinical and translational radiation oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Target volume and organ of interest (OOI) contouring and treatment planning for Methods: Five experts established consensus delineations for target volumes and defined OOI in two Results: Median dice similarity coefficient (DSC) for clinical target volume (CTV) was 0.92 for both cases, whereas the median 95th percentile Hausdorff distance for CTV was 0.54 cm and 0.65 cm. Larger variability in DSC and volume size was seen for OOI, e.g., a median DSC of 0.47 and 0.64 for the optic chiasm and between 0.61 and 0.77 for the hippocampi. DSC-derived DLS-values were within the range of manual delineations for all OOI. Conclusions: Delineation variation between study centers was minor for target volumes, especially for DSC of CTV. Variability was considerably higher for several OOI, representing a potential hazard not least with new and more precise radiotherapy techniques. Interestingly, DLS performed OOI-segmentation within the range of manual experts and represents a reasonable OOI-segmentation alternative in the future.
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