ArticleFrontiers in medicine2026
Effects of problem-focused versus emotion-focused behavioral interventions on peptic ulcer recurrence: a 4-year retrospective cohort study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Peptic ulcer disease (PUD) exhibits high recurrence rates, and behavioral interventions targeting coping strategies may influence long-term outcomes. However, the differential associations of problem-focused versus emotion-focused structured interventions with ulcer recurrence remain unclear. Objective: To evaluate the association between problem-focused versus emotion-focused behavioral interventions delivered during hospitalization and subsequent 4-year ulcer recurrence in patients with PUD. Methods: This single-center retrospective cohort study included 167 patients hospitalized with PUD between January 2021 and March 2025. Based on documented structured interventions received during the index hospitalization, patients were classified into a problem-focused intervention group ( Results: Over the 4-year observation period, cumulative ulcer recurrence was significantly lower in the problem-focused group (19.05% vs. 37.35%; χ Conclusion: In this retrospective cohort, receipt of a structured problem-focused behavioral intervention during hospitalization was associated with lower ulcer recurrence and improved clinical outcomes over the 4-year observation period compared to an emotion-focused intervention. However, given the observational design, single-center setting, lack of participant blinding, and potential residual confounding, these findings should be interpreted as hypothesis-generating. Prospective randomized controlled trials are warranted to establish causality and evaluate generalizability before integration into routine clinical practice.
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