ArticleFrontiers in medicine2026
Immune checkpoint inhibitor-induced hypopituitarism presenting as postoperative hyponatremia in a gastric cancer patient: a case report.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This report describes a gastric cancer patient who developed persistent postoperative hyponatremia following surgery, ultimately associated with immune checkpoint inhibitor-induced hypopituitarism with secondary adrenal insufficiency. Initial symptoms, including diarrhea, abdominal pain, and hyponatremia, were misattributed to common postoperative complications. Laboratory testing, including ACTH and cortisol levels, confirmed pituitary insufficiency. Steroid replacement therapy led to rapid symptom improvement and stabilization. This case highlights an underrecognized endocrine complication of immune checkpoint inhibitor therapy, emphasizing the need for early recognition, careful monitoring of endocrine function, and multidisciplinary management in postoperative cancer care.
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