Evidence map›Paper›PMID 42383004›Full record

ArticleiScience2026

Single-cell RNA profiling of oligodendroglial lineage cells derived from iPSCs carrying Parkinson's disease-relevant LRRK2-G2019S mutation.

Nasser Karmali, Wiebke Kessler, Mohammad Dehestani, Wenhua Sun, Layla Drwesh, Polina Volos, Stanislav Tsitkov, Ashutosh Dhingra, Christian Thomas, Salvador Rodriguez-Nieto and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Nasser KarmaliGerman Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen, Germany.
Wiebke KesslerInstitute of Neuropathology, University Hospital Münster, 48149 Münster, Germany.
Mohammad DehestaniGerman Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen, Germany.
Wenhua SunGerman Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen, Germany.
Layla DrweshHertie Institute for Clinical Brain Research, University of Tübingen, 72076 Tübingen, Germany.
Polina VolosInterfaculty Institute of Biochemistry, University of Tübingen, 72076 Tübingen, Germany.
Stanislav TsitkovDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Ashutosh DhingraGerman Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen, Germany.
Christian ThomasInstitute of Neuropathology, University Hospital Münster, 48149 Münster, Germany.
Salvador Rodriguez-NietoGerman Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen, Germany.
Julia TietzInstitute of Translational Neurology, University Hospital Münster, 48149 Münster, Germany.
David SchafflickInstitute of Translational Neurology, University Hospital Münster, 48149 Münster, Germany.
Noémia FernandesGerman Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen, Germany.
Julia FitzgeraldHertie Institute for Clinical Brain Research, University of Tübingen, 72076 Tübingen, Germany.
Ernest FraenkelDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Thomas GasserGerman Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen, Germany.
Nisha Mohd RafiqInterfaculty Institute of Biochemistry, University of Tübingen, 72076 Tübingen, Germany.
Tanja KuhlmannInstitute of Neuropathology, University Hospital Münster, 48149 Münster, Germany.
Vikas BansalGerman Center for Neurodegenerative Diseases (DZNE), 72076 Tübingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent findings indicate oligodendrocytes (ODCs) and their progenitors are vulnerable in Parkinson's disease (PD) pathogenesis. Notably, oligodendrocyte precursor cells (OPCs) exhibit high endogenous expression of the PD-relevant gene

Indexed as

ciliahedgehogiPSCsLRRK2oligodendrocyte precursor cellsoligodendrocytesParkinson's diseasescRNA-seqsemaphorin-plexin

Identifiers

PMID42383004
PMCPMC13315888

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.