ArticleiScience2026
STEMIN- and YAP5SA-induced exosomes prevent cardiomyocyte apoptosis.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
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Abstract
Cardiac regeneration strategies increasingly leverage transient reprogramming to restore function in damaged myocardium. Here, we show that delivery of modRNA encoding STEMIN, a modified serum response factor, together with YAP5SA, a constitutively active YAP1 variant, induces coordinated chromatin remodeling and transcriptional reprogramming in cardiomyocytes. Using ATAC-seq and RNA-seq in rat and human cardiomyocytes, we identify the activation of cell cycle, DNA replication, and survival-associated pathways, alongside a robust induction of microRNAs linked to apoptosis resistance. Exosome profiling reveals selective packaging and release of these miRNAs, which may target key regulators of intrinsic and extrinsic apoptotic pathways, including caspases and TP53-associated signaling. Functional assays demonstrate reduced apoptosis
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Registered trials
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