Evidence map›Paper›PMID 42382994›Full record

ArticleiScience2026

Deletion of Snap25 disrupts glial remodeling in aging mouse brain.

Auguste Vadisiute, Florina Szabo, Sofia Luchanskaya, Vanessa Drevenakova, Fernando Messore, Albert Ugwudike, Gretchen Greene, Marissa Mueller, Sophie V Morse, Anna Hoerder-Suabedissen and 1 more

Abstract read
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In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Auguste VadisiuteDepartment of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Oxford, UK.
Florina SzaboDepartment of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Oxford, UK.
Sofia LuchanskayaDepartment of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Oxford, UK.
Vanessa DrevenakovaDepartment of Bioengineering, Imperial College London, London, UK.
Fernando MessoreDepartment of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Oxford, UK.
Albert UgwudikeDepartment of Bioengineering, Imperial College London, London, UK.
Gretchen GreeneDepartment of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Oxford, UK.
Marissa MuellerDepartment of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Oxford, UK.
Sophie V MorseDepartment of Bioengineering, Imperial College London, London, UK.
Anna Hoerder-SuabedissenDepartment of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Oxford, UK.
Zoltán MolnárDepartment of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Oxford, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuronal activity regulates glial physiology, but the effects of prolonged synaptic silencing in mature circuits are unclear. Using Rbp4-Cre-mediated Snap25 deletion to block neurotransmitter release in subsets of cortical layer 5 neurons and dentate gyrus granule cells, we examined glial responses across connected brain regions and the spinal cord in adult and middle-aged mice. Silenced cortical regions showed strong astrocytic reactivity and increased microglial density, while downstream targets, including the superior colliculus and CA3, exhibited marked microglial remodeling and synaptic changes. CA1 displayed milder alterations. In the spinal cord, microglial density decreased and GFAP

Indexed as

neuroscience

Identifiers

PMID42382994
PMCPMC13316228

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.