Evidence map›Paper›PMID 42382993›Full record

ArticleiScience2026

Matched sampling reveals uncoupled phenotypic plasticity during metastasis formation in uveal melanoma.

Karim Al-Ghazzawi, Sabrina Borchert, Siyang Liu, Amal R Al Kadi, Fung-Yi Cheung, Georgia Antonopoulou, Tobias Blau, Andreas Junker, Leyla Jabbarli, Sylvia Hartmann and 10 more

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Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Karim Al-GhazzawiDepartment of Ophthalmology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Sabrina BorchertDepartment of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Siyang LiuMedical Faculty, University Duisburg-Essen, 45122 Essen, Germany.
Amal R Al KadiMedical Faculty, University Duisburg-Essen, 45122 Essen, Germany.
Fung-Yi CheungSpatiotemporal Tumor Heterogeneity, German Cancer Consortium (DKTK), Partner Site Essen, A Partnership Between German Cancer Research Center (DKFZ) and University Hospital Essen, Essen, Germany.
Georgia AntonopoulouSpatiotemporal Tumor Heterogeneity, German Cancer Consortium (DKTK), Partner Site Essen, A Partnership Between German Cancer Research Center (DKFZ) and University Hospital Essen, Essen, Germany.
Tobias BlauInstitute of Neuropathology, University Medicine Essen, University of Duisburg-Essen, Essen, Germany.
Andreas JunkerInstitute of Neuropathology, University Medicine Essen, University of Duisburg-Essen, Essen, Germany.
Leyla JabbarliDepartment of Ophthalmology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Sylvia HartmannDepartment of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Olaf D MurasDepartment of Ophthalmology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Michael ZeschnigkInstitute of Human Genetics, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Tobias KieferDepartment of Ophthalmology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Kathy KeyvaniInstitute of Neuropathology, University Medicine Essen, University of Duisburg-Essen, Essen, Germany.
Michael WessollyDepartment of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Miltiadis FiorentzisDepartment of Ophthalmology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Utta Berchner-PfannschmidtDepartment of Ophthalmology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Nikolaos BechrakisDepartment of Ophthalmology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Fabian MairingerDepartment of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Halime KalkavanMedical Faculty, University Duisburg-Essen, 45122 Essen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Uveal melanoma (UM) is a genetically well-defined yet phenotypically diverse malignancy with a strong predilection for liver metastasis. To define phenotypic divergence during progression, we performed comprehensive gene expression profiling of primary UM (pUM) and metastatic UM (mUM) samples. Two principal molecular subtypes emerged in both entities. Matched pUM-mUM samples showed little transcriptional concordance, indicating extensive reprogramming during metastasis. Approximately half of the pUM samples exhibited a proliferative, MAPK/PI3K-driven phenotype, suggesting heterogeneous dependency on PKC signaling. Immune landscapes also diverged; pUM was dominated by adaptive responses, whereas mUM displayed innate signaling and macrophage-driven immunosuppression. The inflammatory pUM-A subtype was associated with poor survival, consistent with The Cancer Genome Atlas (TCGA) data linking chromosomal aberrations such as monosomy 3 to progression. Analysis of 53 UM samples demonstrated context-dependent phenotypes, supporting site-specific, phenotype-guided therapeutic strategies integrating pathway inhibition and immune modulation.

Indexed as

CancerCancer systems biologyImmune system

Identifiers

PMID42382993
PMCPMC13315734

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.