Evidence map›Paper›PMID 42382960›Full record

ArticleInternational journal of ophthalmology2026

Metagenomic analysis of ocular microbiome in aqueous humor from myopia, cataract, primary open angle glaucoma and Posner-Schlossman syndrome.

Wei-Jia Zhang, Zhen Yang, Jian-Qi She, Hong-Ling Wu, Zi-Yao Xia, Di Zhang, Ling-Ge Suo, Zhe Pan, Yu Zhang, Huai-Zhou Wang and 2 more

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Article in International journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Wei-Jia ZhangDepartment of Ophthalmology, Peking University Third Hospital, Beijing 100191, China.
Zhen YangDepartment of Ophthalmology, Peking University Third Hospital, Beijing 100191, China.
Jian-Qi SheDepartment of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China.
Hong-Ling WuBeijing Tsinghua Changgung Hospital Eye Center, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing 102218, China.
Zi-Yao XiaBeijing Tsinghua Changgung Hospital Eye Center, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing 102218, China.
Di ZhangBeijing Tsinghua Changgung Hospital Eye Center, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing 102218, China.
Ling-Ge SuoDepartment of Ophthalmology, Peking University Third Hospital, Beijing 100191, China.
Zhe PanBeijing Tsinghua Changgung Hospital Eye Center, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing 102218, China.
Yu ZhangDepartment of Ophthalmology, Peking University Third Hospital, Beijing 100191, China.
Huai-Zhou WangBeijing Tsinghua Changgung Hospital Eye Center, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing 102218, China.
Jing HongDepartment of Ophthalmology, Peking University Third Hospital, Beijing 100191, China.
Chun ZhangBeijing Tsinghua Changgung Hospital Eye Center, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing 102218, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo characterize the composition and functional features of the aqueous humor microbiome in common ocular diseases, including myopia, cataract, primary open angle glaucoma (POAG), and Posner-Schlossman syndrome (PSS).

methodsWe performed metagenomic sequencing on 176 aqueous humor samples from patients with cataract (

resultsWe identified 6635 bacterial, 141 archaeal, 96 eukaryotic, and 108 viral operational taxonomic units (OTUs) in the aqueous humor. The microbiome was dominated by

conclusionThis study provides a preliminary characterization of the aqueous humor microbiome in patients with POAG, PSS, cataract, and myopia controls. The identified microbial signatures and functional pathways offer new insights into potential microbiome-mediated mechanisms in ocular pathophysiology and may inform future diagnostic and therapeutic strategies.

Indexed as

aqueous humorcataractmicrobiomePosner-Schlossman syndromeprimary open angle glaucoma

Identifiers

PMID42382960
PMCPMC13314668

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.