ArticleInternational journal of ophthalmology2026
Diagnostic value of OCT-based temporal macular retinal thinning in children with hereditary glomerular diseases.
Article in International journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimTo determine the differences in temporal macular thinning among children with Alport syndrome (AS), thin basement membrane nephropathy (TBMN), and age-matched healthy controls and to clarify its diagnostic and differential diagnostic significance.
methodsThis was a case-control study. Children with AS and TBMN diagnosed at our hospital between January 2021 and December 2024 were enrolled. All participants underwent comprehensive ophthalmic assessments, including visual acuity, refraction, slit-lamp biomicroscopy with dilated pupils, color fundus photography, biometry, and optical coherence tomography (OCT). Refractive error, lens thickness, axial length, macular retinal thickness in all sectors, and temporal thinning index (TTI) values were compared using one-way analysis of variance (ANOVA) or an independent samples
resultsThe cohort consisted of 40 patients with genetically confirmed AS [33 with X-linked Alport syndrome (XLAS): 16 males, 17 females; 7 with autosomal recessive Alport syndrome (ARAS): 4 males, 3 females], 40 patients with TBMN (male:female=1:1, 40 eyes), and 40 age-matched healthy controls (male:female=1:1, 40 eyes). The standard deviations of the mean TTI values were 12.08±3.18 in the AS group, 6.60±1.88 in the TBMN group, and 6.42±1.14 in the control group. The TTI was significantly greater in the AS group than in both the TBMN and control groups (
conclusionChildren with AS exhibit greater temporal macular retinal thinning than do those with TBMN and healthy controls. The TTI shows potential as an auxiliary diagnostic marker for AS in male patients.
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