Evidence map›Paper›PMID 42382925›Full record

SynthesisFrontiers in oral health2026

Splintless approach improves surgical accuracy in Le Fort I osteotomies: a systematic review and meta-analysis.

Darius Sandu, Bianca G N Cavalcante, Gábor Varga, Bence Szabo, Alexander Schulze Wenning, Mojtaba Dahmardeh, Eniko V Szabó, Peter Hegyi, Gábor Gerber, Victor-Vlad Costan

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Darius SanduCentre for Translational Medicine, Semmelweis University, Budapest, Hungary.
Bianca G N CavalcanteCentre for Translational Medicine, Semmelweis University, Budapest, Hungary.
Gábor VargaCentre for Translational Medicine, Semmelweis University, Budapest, Hungary.
Bence SzaboCentre for Translational Medicine, Semmelweis University, Budapest, Hungary.
Alexander Schulze WenningCentre for Translational Medicine, Semmelweis University, Budapest, Hungary.
Mojtaba DahmardehCentre for Translational Medicine, Semmelweis University, Budapest, Hungary.
Eniko V SzabóCentre for Translational Medicine, Semmelweis University, Budapest, Hungary.
Peter HegyiCentre for Translational Medicine, Semmelweis University, Budapest, Hungary.
Gábor GerberCentre for Translational Medicine, Semmelweis University, Budapest, Hungary.
Victor-Vlad CostanCentre for Translational Medicine, Semmelweis University, Budapest, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Accurate bone repositioning is crucial during orthognathic surgery (OS), as even slight deviations from the planned position can impact function and esthetics. As splintless techniques are rapidly evolving, patient-specific implants (PSI) and digital surgical templates (DST) are establishing new standards. This systematic review and meta-analysis aimed to assess the effectiveness of splintless OS compared to virtually planned splints. Materials and methods: We conducted our study in accordance with the guidelines of the PRISMA 2020 framework. A systematic search was performed on November 15, 2024, across PubMed, Embase, and Cochrane. We included randomized controlled clinical trials and observational studies. The primary outcome was surgical accuracy, assessed by the mean linear and angular deviation across the three spatial axes. Results: Among the 8,563 identified studies, sixteen met inclusion criteria, and nine were subsequently pooled for meta-analysis. Findings were statistically significant for splintless OS concerning linear deviation along the anteroposterior (MD = -0.49 mm; 95% CI: [-0.73, -0.26]), vertical (MD = -0.32; 95% CI: [-0.53, -0.11]), and mediolateral (MD = -0.37; 95% CI: [-0.59, -0.15]) axes. In terms of angular deviation, PSI showed significant results with reduced discrepancies around the anteroposterior axis (roll) (MD = -0.48; 95% CI: [-0.88, -0.08]). The results did not achieve statistical significance in yaw (MD = -0.71; 95% CI: [-1.50; 0.09]) or pitch (MD = -0.57; 95% CI: [-1.45; 0.31]). However, surgical accuracy has shown consistent improvement across studies. Conclusion: Splintless OS consistently showed significantly lower mean deviations from the planned position, outperforming splint-based OS. These results indicate that PSI and DST may offer superior surgical accuracy compared to virtually planned splints. DST may be a valuable, potentially lower-cost alternative, providing the same clinical benefits as PSI. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024605292.

Indexed as

accuracyBSSOCAD/CAM splintsLeFort Iorthognathic surgerypatient-specific implantssurgical templates

Identifiers

PMID42382925
PMCPMC13316659

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.