Evidence map›Paper›PMID 42382823›Full record

ArticleOphthalmology science2026

Regional Biomechanical and Topographic Changes after Transepithelial vs. Epithelium-off Continuous Accelerated Corneal Cross-linking in Keratoconus: Updated Stress-Strain Index as a Superior Biomarker.

BangXun Mao, ChangChang He, Qian Ye, WeiJia Liu, YiQian Li, Daniela Oehring, YuKe Zhang, XiaoMeng Li, ChenHao Zhao, HongJie Hu and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ophthalmology science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

BangXun MaoNational Clinical Research Center for Ocular Diseases, Eye Hospital, WenZhou Medical University, Wenzhou, China.
ChangChang HeNational Clinical Research Center for Ocular Diseases, Eye Hospital, WenZhou Medical University, Wenzhou, China.
Qian YeNational Clinical Research Center for Ocular Diseases, Eye Hospital, WenZhou Medical University, Wenzhou, China.
WeiJia LiuMedical Sciences Division, University of Oxford, Oxford, UK.
YiQian LiNational Clinical Research Center for Ocular Diseases, Eye Hospital, WenZhou Medical University, Wenzhou, China.
Daniela OehringSchool of Health Professions, University of Plymouth, Plymouth, UK.
YuKe ZhangNational Clinical Research Center for Ocular Diseases, Eye Hospital, WenZhou Medical University, Wenzhou, China.
XiaoMeng LiNational Clinical Research Center for Ocular Diseases, Eye Hospital, WenZhou Medical University, Wenzhou, China.
ChenHao ZhaoNational Clinical Research Center for Ocular Diseases, Eye Hospital, WenZhou Medical University, Wenzhou, China.
HongJie HuNational Clinical Research Center for Ocular Diseases, Eye Hospital, WenZhou Medical University, Wenzhou, China.
JiaWei GongNational Clinical Research Center for Ocular Diseases, Eye Hospital, WenZhou Medical University, Wenzhou, China.
HanHui HouNational Clinical Research Center for Ocular Diseases, Eye Hospital, WenZhou Medical University, Wenzhou, China.
YuFeng YeNational Clinical Research Center for Ocular Diseases, Eye Hospital, WenZhou Medical University, Wenzhou, China.
ShiHao ChenNational Clinical Research Center for Ocular Diseases, Eye Hospital, WenZhou Medical University, Wenzhou, China.
YiYu LiNational Clinical Research Center for Ocular Diseases, Eye Hospital, WenZhou Medical University, Wenzhou, China.
Ahmed ElsheikhZheJiang-United Kingdom Joint Laboratory on Ocular biomechanics, Wenzhou, China.
FangJun BaoNational Clinical Research Center for Ocular Diseases, Eye Hospital, WenZhou Medical University, Wenzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To compare regional biomechanical and topographic outcomes between transepithelial (Epi-on) and epithelium-off (Epi-off) continuous accelerated corneal cross-linking (ACXL) in keratoconus. Design: A retrospective cohort study. Subjects: Seventy-seven keratoconic eyes were included: 45 with Epi-on ACXL and 32 with Epi-off ACXL. Methods: All eyes underwent ACXL (10 mW/cm Main Outcome Measures: Regional changes in SSIv2 Results: At 6 months, SSIv2 Conclusions: Epi-off ACXL induces stronger and more durable biomechanical stiffening and central flattening than Epi-on ACXL. Biomechanical parameters, particularly SSIv2, were more sensitive than curvature-based metrics for detecting regional treatment effects. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Indexed as

Corneal cross-linkingCorneal shapeKeratoconusOcular biomechanicsRegional variation

Identifiers

PMID42382823
PMCPMC13316749

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.