Evidence map›Paper›PMID 42382774›Full record

ArticleFrontiers in immunology2026

HLA DP/DRA molecule regulates systemic inflammation and neuroinflammation, aggravates cognitive impairment and long-term anxiety in murine model of sepsis-associated encephalopathy.

Feng Li, Bowen Niu, Yu Huang, Mengmin Zhu, Lingling Liu, Lixiang Chen, Hua Yang, Boyin Qin, Xiaohui Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Feng LiDepartment of Laboratory Animal Science, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Bowen Niu *Department of Laboratory Animal Science, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Yu Huang *Department of Biology, College of Life Sciences, Shanghai Normal University, Shanghai, China.
Mengmin ZhuDepartment of Laboratory Animal Science, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Lingling LiuDepartment of Laboratory Animal Science, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Lixiang ChenDepartment of Laboratory Animal Science, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Hua YangDepartment of Laboratory Animal Science, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Boyin QinDepartment of Laboratory Animal Science, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Xiaohui ZhouDepartment of Laboratory Animal Science, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sepsis-associated encephalopathy (SAE) is a severe and common neurological complication of sepsis, characterized by symptoms ranging from mild confusion, delirium, deep coma, and severe cognitive dysfunction. Previous epidemiological and bioinformatics studies have revealed that HLA DP and DRA molecule play a pivotal role during sepsis. However, the mechanism by which these class II molecule contribute to cognitive impairment in SAE remains unclear. using the peritoneal contamination and infection model (PCI) model in humanized transgenic HLA-DP401/DRA-IAβ

Indexed as

AnxietyCognitive DysfunctionHLA-DR alpha-ChainsNeuroinflammatory DiseasesSepsis-Associated EncephalopathyAnimalsCytokinesDisease Models, AnimalHippocampusHumansInflammationMaleMiceMice, KnockoutMice, TransgenicSepsisCytokinesHLA-DR alpha-Chainsanxietycognitive impairmenthippocampusHLA-DP401HLA-DRAinflammationMHC class IIsepsis

Identifiers

PMID42382774
PMCPMC13314453

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.