Evidence map›Paper›PMID 42382720›Full record

ArticleMaterials today. Bio2026

A flexibility-driven delivery strategy for cationic liposomes to enhance tumor penetration and promote membrane fusion-mediated cellular entry.

Lifeng Luo, Xiaonan Liu, Yuqing Cai, Yiran Zhang, Yifan Zhao, Zhenqiang Song, Ziwen Meng, Tian Xie, Fenghua Meng, Wenxing Gu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lifeng LuoSchool of Pharmacy, Zhejiang Provincial Key Laboratory of Anti-Cancer Chinese Medicines and Natural Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, 311121, PR China.
Xiaonan LiuSchool of Pharmacy, Zhejiang Provincial Key Laboratory of Anti-Cancer Chinese Medicines and Natural Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, 311121, PR China.
Yuqing CaiSchool of Pharmacy, Zhejiang Provincial Key Laboratory of Anti-Cancer Chinese Medicines and Natural Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, 311121, PR China.
Yiran ZhangSchool of Pharmacy, Zhejiang Provincial Key Laboratory of Anti-Cancer Chinese Medicines and Natural Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, 311121, PR China.
Yifan ZhaoSchool of Pharmacy, Zhejiang Provincial Key Laboratory of Anti-Cancer Chinese Medicines and Natural Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, 311121, PR China.
Zhenqiang SongSchool of Pharmacy, Zhejiang Provincial Key Laboratory of Anti-Cancer Chinese Medicines and Natural Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, 311121, PR China.
Ziwen MengSchool of Pharmacy, Zhejiang Provincial Key Laboratory of Anti-Cancer Chinese Medicines and Natural Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, 311121, PR China.
Tian XieSchool of Pharmacy, Zhejiang Provincial Key Laboratory of Anti-Cancer Chinese Medicines and Natural Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, 311121, PR China.
Fenghua MengBiomedical Polymers Laboratory, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, PR China.
Wenxing GuSchool of Pharmacy, Zhejiang Provincial Key Laboratory of Anti-Cancer Chinese Medicines and Natural Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, 311121, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cationic liposomes have emerged as a promising delivery vehicle for chemotherapy. However, their strong electrostatic interaction with tumor vascular endothelium and stroma lead to predominant accumulation at the periphery, thereby restricting deep tumor penetration. Herein, we propose a mechanical programming strategy that modulates the flexibility of cationic liposomes to enhance their tissue permeability, delivery efficiency and antitumor efficacy. By incorporating sodium cholate as a flexibilizer, we engineered a cabazitaxel (CTX)-loaded cationic flexible liposome (CTX@CFL) with enhanced membrane fluidity and deformability. This flexibility-driven redesign shifted the cellular uptake mechanism from endocytosis to membrane fusion, facilitating direct cytosolic delivery and bypassing lysosomal degradation. Consequently, CTX@CFL demonstrated superior transendothelial transport, significantly deeper tumor penetration, and enhanced cytotoxicity compared to conventional cationic rigid liposomes.

Indexed as

Cationic liposomeFlexibilityMembrane fusionSodium cholateTumor permeation

Identifiers

PMID42382720
PMCPMC13316053

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.