ArticleExploration (Beijing, China)2026
Peptide RL-QN15 Regulates Functions of Epidermal Stem Cells to Accelerate Skin Wound Regeneration via the FZD8/β-Catenin Axis.
Article in Exploration (Beijing, China), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Fufang Huangbo Formula mitigates myeloproliferative neoplasms by activating p53/p21 signaling axis and inhibiting STAT3 and NF-κB signaling pathways.Pharmaceutical science advances · 2026Article
- Multifunctional Polyphenol-Polymer Nanocomposite Hydrogel Targeting Inflammation, Oxidative Stress, and Infection in Diabetic Wounds.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Immunoregulatory properties of the human acellular amniotic membrane for diabetic wound healing.iScience · 2026Article
- An Innovative Sprayable Mg-MOF Hydrogel Enhances Healing of Chronic Wounds with Multifaceted Pathologies in a Porcine Model.ACS nano · 2026Article
- A tree-inspired liquid-managing scaffold with radial-axial continuity for wound exudate management.Materials today. Bio · 2026Article
- Hypoxia-preconditioned adipose-derived mesenchymal stem cells-derived exosomes transferring H19 obstruct neutrophil extracellular traps formation via HOXA5-mediated inactivation of TLR4/NF-κB/NLRP3 inflammatory signaling.Journal of diabetes investigation · 2026Article
- Pirfenidone Ameliorates Paraquat-Induced Epithelial-Mesenchymal Transition via miR-9-8974-5p/RGS2 Axis.Advanced biology · 2026Article
- Peptide RL-QN15 Regulates Functions of Epidermal Stem Cells to Accelerate Skin Wound Regeneration via the FZD8/β-Catenin Axis.Exploration (Beijing, China) · 2026Article
- Janus nanomotors for topical treatment of radiation-induced dermatitis.Nature communications · 2026Article
- Sustained-release CGRP microspheres accelerate diabetic wound healing by synergistically promoting neurovascular regeneration through modulation of macrophage and endothelial cell functions.Materials today. Bio · 2026Article
- Development and In Vitro Characterization of Light Responsive Zinc-Based Nanoparticles Embedded in Collagen Sheets Intended for Wound Care Oriented Applications.Macromolecular bioscience · 2026Article
- The role and mechanism by which micropeptide WHPP promote refractory wound healing.Journal of translational medicine · 2026Article
- Barrier-disrupting microneedle technology: Overcoming physical, physiological, and pathological skin defenses to enhance therapeutic efficacy.Bioactive materials · 2026Review
- Molecular mechanism of phosphate import by the bacterial PstSCAB transporter.Nature communications · 2026Article
- Protective Effect of Multifloral Honey on Stem Cell Aging in a Dynamic Cell Culture Model.Antioxidants (Basel, Switzerland) · 2026Article
- Therapeutic Potential of the ApoE-Mimicked Peptide COG133: Regulation of miRNA146‑a in Diabetic Fibroblasts and Antibacterial Activity.ACS omega · 2026Article
- Comparative regenerative mechanisms of adipose-derived mesenchymal stem cell- and conditioned medium-loaded three-dimensional bioprinted hydrogels in chronic diabetic wounds.Regenerative biomaterials · 2026Article
- Potential Application of Plant-Derived Extracellular Vesicles in Treatment of Burn Wounds.International journal of nanomedicine · 2026Review
- Sulfated Polysaccharides in Wound Healing: From Bioactive Materials Design to Regenerative Therapeutics.International journal of nanomedicine · 2026Review
- Multifunctional pH-responsive HA-c-FZ1 hydrogel presents a promising therapeutic strategy for diabetic skin wounds.Burns & trauma · 2026Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pursuit of developing groundbreaking pro-regenerative therapies to expedite skin wound healing persists as a formidable challenge. Peptide RL-QN15, emerges as a highly promising candidate for the first pro-regenerative drug derived from amphibian skin, offering a glimmer of hope for innovative healing treatments. Yet, there is an urgent need for intensified research efforts to propel RL-QN15 from a molecular entity to a viable drug candidate, particularly in unraveling the mechanisms underlying its exceptional pro-healing efficacy. In the current research, our results revealed that RL-QN15 significantly enhanced the proliferation, migration, stemness, and epithelial-to-mesenchymal transition of human epidermal stem cells (hESCs) through direct binding to the membrane frizzled 8 (FZD8) receptor. This interaction triggers the downstream Wnt/β-catenin signaling pathway, leading to the up-regulation of target genes MYC and CCND1. Furthermore, RL-QN15 augmented the expression and secretion of matrix metalloproteinase-3, which degrades E-cadherin and activates the Wnt/β-catenin pathway, thereby amplifying RL-QN15's regulatory effects on hESCs. In summary, our findings have demonstrated that RL-QN15 modulated the functions of ESCs to accelerate skin wound regeneration via the FZD8/β-catenin axis. This research not only advances peptide RL-QN15 from a molecular entity to a drug candidate by shedding light on the mechanisms involved with regulation of ESCs functions, but also presents compelling evidence implicating FZD8 as a novel therapeutic target for skin wound regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.