Evidence map›Paper›PMID 42382641›Full record

ArticleFrontiers in bioinformatics2026

Hydrogen sulfide modulates gene networks in hypoxia/reoxygenation-stressed trophoblasts: insights from transcriptome profiling.

Shivani, Amit Katiyar, Sunil Kumar Gupta, Pallavi Arora, Kiran Kumari, Tooba Tahreem Khan, Pallavi Kshetrapal, Renu Dhingra

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioinformatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

ShivaniDepartment of Anatomy, All India Institute of Medical Sciences, New Delhi, India.
Amit KatiyarBioinformatics Facility, Centralized Core Research Facility, All India Institute of Medical Sciences, New Delhi, India.
Sunil Kumar GuptaDepartment of Anatomy, All India Institute of Medical Sciences, New Delhi, India.
Pallavi AroraDepartment of Anatomy, All India Institute of Medical Sciences, New Delhi, India.
Kiran KumariDepartment of Biotechnology, All India Institute of Medical Sciences, New Delhi, India.
Tooba Tahreem KhanDepartment of Anatomy, All India Institute of Medical Sciences, New Delhi, India.
Pallavi KshetrapalLab of Perinatal Research, BRIC-Translational Health Science and Technology Institute, Faridabad, Haryana, India.
Renu DhingraDepartment of Anatomy, All India Institute of Medical Sciences, New Delhi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Hydrogen sulfide is an endogenous gaseous signalling molecule with recognized roles in vascular regulation, redox homeostasis, and inflammation. In the placenta, H Methods: HTR-8/SVneo trophoblasts were subjected to H/R injury induced by varying oxygen concentrations to model the fluctuating oxygen environments of early placental development, followed by treatment with an exogenous H Results: H/R induced extensive transcriptional remodelling, with robust activation of HIF-1, PI3K-Akt, MAPK, Rap1/Ras, NF-κB, and focal adhesion pathways. H/R [2/10% O Discussion: Our study provides the first evidence of transcriptomic analysis showing that H

Indexed as

cystathionine gamma lyasehydrogen sulphidehypoxia/reoxygenation injurypreeclampsiatranscriptomictrophoblast

Identifiers

PMID42382641
PMCPMC13314452

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.