ArticleCase reports in women's health2026
From presumed infection to systemic vasculitis: de novo granulomatosis with polyangiitis in pregnancy - a case report.
Article in Case reports in women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Granulomatosis with polyangiitis (GPA) is a rare ANCA-associated vasculitis. De novo presentation during pregnancy is exceptionally rare and may mimic severe infection, delaying diagnosis. This report concerns a case of new-onset GPA in a 26-year-old primigravid woman presenting in the second trimester with progressive refractory sinonasal disease initially treated as severe bacterial sinusitis. Despite repeated antimicrobial therapy and multiple ENT interventions, her condition deteriorated with development of hemoptysis and cavitating pulmonary lesions. Histopathology demonstrated necrotizing granulomatous inflammation, and further evaluation revealed ANCA positivity with anti-PR3 antibodies, confirming GPA at approximately 22 weeks of gestation. Management was complicated by rapidly progressive multisystem disease, concern for evolving renal involvement, opportunistic pulmonary infection with
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