ArticleBasic and clinical neuroscience
Effectiveness of Low-frequency rTMS and CBT in Reducing Symptoms Severity and Improving Cognitive Flexibility in Adults With OCD: A Clinical Trial.
Article in Basic and clinical neuroscience. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: This study aims to assess and compare the effects of low-frequency (LF) repetitive transcranial magnetic stimulation (rTMS) and cognitive-behavioral therapy (CBT) on symptoms and cognitive flexibility of adults with obsessive-compulsive disorder (OCD). Methods: This is a randomized clinical trial conducted on 24 people with OCD living in Zanjan City, Iran, in two groups of CBT (n=12) and rTMS (n=12). The CBT with exposure and response prevention (ERP) was presented at 20 sessions. The rTMS (1 Hz) was delivered at 100 resting motor thresholds using an 8-shaped coil over the right dorsolateral prefrontal cortex (DLPFC) (F4) for 2 weeks at 10 sessions. They completed the Yale-Brown obsessive-compulsive scale (Y-BOCS) and the cognitive flexibility inventory (CFI) before, immediately, and one month after the intervention. Collected data were analyzed in SPSS software, version 22. Results: Results showed a significant difference between the two groups in the severity of OCD symptoms (obsessions and compulsions) immediately after the intervention (P<0.001), where higher reductions were observed in the CBT group. There was no significant difference between the two groups in cognitive flexibility (P>0.05). No significant difference was found between the groups in any study variable one month after interventions. Conclusion: There is a significant difference between CBT and LF-rTMS techniques in reducing the severity of OCD symptoms, while there is no difference between them in improving the cognitive flexibility of the patients.
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