ArticleBasic and clinical neuroscience
Synergistic Effects of Cerebrolysin and Aerobic Exercise on 6-hydroxydopamine-induced Model of Parkinson Disease in Adult Male Rats.
Article in Basic and clinical neuroscience. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Neurotrophic factors and physical activities have beneficial effects on neurodegenerative disorders. This study assessed the impact of physical exercise (EXE) and cerebrolysin (CBL), individually or in combination, in a Parkinson's disease (PD) model caused by 6-hydroxydopamine (6-OHDA). Methods: The study utilized 62 male Wistar rats, which were divided into six groups (n=12): Sham (received intra substantia nigra [SN] injection of normal saline), PD (underwent 12.5 μg injection of 6-OHDA into the left SN), PD+levodopa (treated with levodopa; 12 mg/kg, gavage, for three weeks), PD+CBL (treated with intraperitoneal injection of CBL 2.5 mL/kg, for three weeks), PD+EXE (exercised 30 min/d for three weeks), and PD+CBL+EXE. Rotation with apomorphine and Murprogo's test was assessed 21 days after PD induction and after treatments. Ultimately, the levels of lipid peroxidation marker and total antioxidant capacity (TAC), glutathione peroxidase (GPx) activity, α-synuclein protein expression, and histopathological changes of the SN were evaluated ipsilateral to the lesioned side. Results: The results showed that CBL and exercise, alone or in combination, decreased ipsilateral apomorphine rotation and muscle rigidity in the PD animals. Moreover, these behavioral changes were associated with reduced malondialdehyde (MDA) levels and α-synuclein protein levels, increased TAC level and GPx activity, and a greater neuronal count in the SN. Notably, the combination effects were greater than single therapy and levodopa treatment. Conclusion: Our findings indicate that the combination of exercise and CBL ameliorated 6-OHDA-induced motor impairments by attenuating oxidative stress and protein expression of α-synuclein and preserving neurons in the SN.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.