Evidence map›Paper›PMID 42382426›Full record

ArticleClinical neurophysiology practice2026

Sympathetic skin response in fibromyalgia patients with small fibre pathology.

Elena Ammendola, Giulia Paparella, Emmanuella Ladisa, Giusy Tancredi, Giulia Paparella, Grazia Devigili, Marianna Diletta Delussi, Katia Ricci, Livio Clemente, Marina de Tommaso

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Article in Clinical neurophysiology practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Elena AmmendolaNeurophysiopathology Unit, Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.
Giulia PaparellaNeurophysiopathology Unit, Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.
Emmanuella LadisaNeurophysiopathology Unit, Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.
Giusy TancrediNeurophysiopathology Unit, Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.
Giulia PaparellaNeurophysiopathology Unit, Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.
Grazia DevigiliMovement Disorders Unit, Clinical Neurophysiology Unit Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Marianna Diletta DelussiDepartment of Education, Psychology, Communication (For.Psi.Com.), University of Bari Aldo Moro, Bari, Italy.
Katia RicciNeurophysiopathology Unit, Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.
Livio ClementeNeurophysiopathology Unit, Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.
Marina de TommasoNeurophysiopathology Unit, Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveFibromyalgia (FM) is a chronic disease characterised by small fibre pathology and autonomic dysfunction. Sympathetic Skin Response (SSR) can be easily obtained in clinical practice as a marker of autonomic dysfunction. This study aims to assess SSR abnormalities in small fibre pathology associated with FM.

methodsThis was a retrospective, observational, single-centre, cross-sectional study including 393 patients with FM, who underwent skin biopsy from the thigh and ankle, SSR obtained with a standard electromyographic active electrode attached to the right palm and sole, and clinical evaluation.

resultsSSR at the hand and foot was similarly absent in patients with both normal and abnormal skin biopsy results. Hand amplitude was reduced in patients with denervation (Wilcoxon z = 1.89,

conclusionsSSR abnormalities did not correspond to small fibre impairment detected by skin biopsy in patients with FM. SIGNIFICANCE: SSR and skin biopsy may capture different aspects of the complex clinical picture of FM, including psychopathological features and fatigue, and therefore represent complementary yet distinct biomarkers of the disease.

Indexed as

Autonomic dysfunctionFibromyalgiaSmall fibre pathologySympathetic skin response

Identifiers

PMID42382426
PMCPMC13315763

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.