Evidence map›Paper›PMID 42382416›Full record

ArticleEClinicalMedicine2026

Therapy and biomarker dependent progression-free survival in infant sonic hedgehog medulloblastoma: a multi-national retrospective cohort study.

Stacey Richardson, Debbie Hicks, Melissa Gough, Ellie R Butler, Dean Thompson, Jemma Castle, Stephen Crosier, Miguel Garcia-Ariza, Idoia Martín-Guerrero, Sabine L A Plasschaert and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EClinicalMedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Stacey RichardsonWolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Debbie HicksWolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Melissa GoughWolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Ellie R ButlerWolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Dean ThompsonWolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Jemma CastleWolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Stephen CrosierWolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Miguel Garcia-ArizaBiobizkaia Health Research Institute, Pediatric Hematology and Oncology Unit, Hospital Universitario Cruces, Barakaldo, Spain.
Idoia Martín-GuerreroDepartment of Genetics, Physical Anthropology & Animal Physiology, Biobizkaia Health Research Institute, University of the Basque Country, UPV/EHU, Leioa, Spain.
Sabine L A PlasschaertPrincess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
Franck BourdeautParis-Cité University & SIREDO Oncology Center (Pediatric, Adolescent and Young Adults Oncology), Institut Curie, Paris, France.
Christelle DufourDépartement de Cancérologie de l'Enfant et de l'Adolescent, Gustave Roussy, Paris, France.
Julien Masliah-PlanchonUnité de Génétique Somatique, Institut Curie, Paris, France.
Francesca Romana ButtarelliDipartimento Scienze Oncologiche Radiologiche Anatomo-Patologiche, Sapienza Universita di Roma, Italy.
Veronica BiassoniDipartimento di Ematologia ed Oncoematologica Pediatrica, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Maura MassiminoDipartimento di Ematologia ed Oncoematologica Pediatrica, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Koichi IchimuraDepartment of Pathology, Kyorin University Faculty of Medicine, Tokyo, Japan.
Yonehiro KanemuraDepartment of Biomedical Research and Innovation, Institute for Clinical Research, NHO Osaka National Hospital, Osaka, Japan.
Vijay RamaswamyProgramme in Developmental and Stem Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Amar GajjarDepartment of Pediatric Medicine, St Jude Children's Research Hospital, Memphis, TN, USA.
Marcel KoolDivision of Pediatric Neuro-Oncology (B062), Hopp Children's Cancer Center Heidelberg (KiTZ), German Cancer Research Center (DKFZ), and German Cancer Consortium (DKTK), Heidelberg, Germany.
Andrey KorshunovDivision of Pediatric Neuro-Oncology (B062), Hopp Children's Cancer Center Heidelberg (KiTZ), German Cancer Research Center (DKFZ), and German Cancer Consortium (DKTK), Heidelberg, Germany.
Stefan M PfisterDivision of Pediatric Neuro-Oncology (B062), Hopp Children's Cancer Center Heidelberg (KiTZ), German Cancer Research Center (DKFZ), and German Cancer Consortium (DKTK), Heidelberg, Germany.
Martin MynarekDepartment of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Stefan RutkowskiDepartment of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Edward C SchwalbeWolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Simon BaileyWolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Steven C CliffordWolfson Childhood Cancer Research Centre, Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Medulloblastoma in infants (iMB; aged < 5 years) presents the challenge of achieving cure while minimising deleterious cranio-spinal irradiation (CSI)-associated late-effects. Non-randomised phase 2 studies have examined upfront CSI omission and chemotherapy intensification for favourable-risk desmoplastic/nodular (DN) tumours associated with the sonic hedgehog (SHH) molecular group (iMB Methods: In this international retrospective cohort study, a multi-national cohort of molecularly and clinically annotated iMB Findings: Between January 20, 2018 and October 6, 2021, patient data from 267 infants with SHH medulloblastoma were collected from Canada (n = 74), Germany/USA (n = 67), and the UK (n = 54), alongside national cohorts collected from France (n = 26), Italy (n = 4), Japan (n = 20), the Netherlands (n = 11), and Spain (n = 33). 226 patients with PFS and OS data comprised the iMB survival cohort and were split into upfront treatment groups based on the receipt of RTx (n = 74, 33%) or CTx-only (n = 132, 58%). Among iMB Interpretation: Our findings show that iMB Funding: Cancer Research UK, Children with Cancer UK, Children's Cancer North, Star for Harris, JGW Patterson Foundation, Little Hero and Blue Skye Thinking.

Indexed as

BiomarkersInfantMedulloblastomaPrognosisSHHTherapy

Identifiers

PMID42382416
PMCPMC13316349

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.