ArticleFrontiers in microbiology2026
Antimicrobial resistance and microbiological gap analysis for central nervous system-assocaited bacterial pathogens in Nigeria.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Despite extensive vaccination efforts, central nervous system (CNS) infections remain a significant cause of morbidity and mortality in the African meningitis belt. This burden is increasingly complicated by the rising antimicrobial resistance (AMR) in pathogens not covered by the available vaccines. We mapped pathogen-specific AMR profiles and diagnostic gaps in CNS bacterial pathogens to inform precise microbiology-based interventions for improved surveillance and empiric therapy in Nigeria. Methods: We conducted a retrospective analysis of a three-year national AMR surveillance data, focusing on CNS bacterial pathogens. Data from 25 sentinel laboratories were extracted, analysed and interpreted per CLSI/GLASS standards. AMR profiles and diagnostic gaps were assessed using descriptive statistics and Chi-square tests for demographic and temporal comparisons. Results: Among 84,548 valid cultures from over 26,000 patients, culture positivity rate was higher in females (35.1%) compared to males (28.3%, Conclusion: Species-level identification gaps and high AMR in CNS bacterial pathogens demand targeted microbiological-led diagnostics, including expanded cerebrospinal fluid testing and AST-guided empiric therapy in resource-limited settings.
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