ArticleStructural heart : the journal of the Heart Team2026
Prognostic Utility of the Dicrotic Notch Index in Patients Undergoing Transcatheter Aortic Valve Replacement.
Article in Structural heart : the journal of the Heart Team, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The dicrotic notch (DN) on the central aortic pressure waveform reflects aortic valve closure. We aimed to assess the clinical utility of the DN index (DNI) in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement (TAVR). Methods: In this retrospective study, we analyzed 569 patients with aortic stenosis who underwent TAVR between January 2019 and December 2020. Aortic waveform data were used to measure systolic, diastolic, and DN pressures, whereas DNI was calculated as (systolic pressure - DN)/pulse pressure. Pre-TAVR and post-TAVR hemodynamic parameters were compared, and survival analysis was performed using Cox regression with post-TAVR/pre-TAVR DNI ratio as an independent covariate. Results: Compared to pre-TAVR, DN pressure (92.18 to 95.37, Conclusions: More than 20% increase in DNI post-TAVR was associated with a lower long-term risk of all-cause mortality. Further studies are needed to understand the determinants of the increase in DNI and if this can be modulated by procedural modifications.
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