ArticleFrontiers in pharmacology2026
Immunomodulatory effects of Yang He decoction on cyclophosphamide-induced immunosuppression in mice: restoration of immune organ integrity and cytokine balance.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To evaluate the protective effects and potential mechanisms of Yang He decoction (YHD), a classic traditional Chinese medicine formula, against cyclophosphamide (CTX)-induced immunosuppression in mice. Methods: An immunosuppression model was established in Kunming mice Results: YHD treatment significantly ameliorated CTX-induced immunosuppression. The medium dose (100 mg/kg) increased body weight by 58.5% (vs. 17.3% in the APS group), restored the spleen index to 9.41 ± 0.94 (0.52-fold vs. Model group 1.8 ± 0.3), and enhanced ConA-stimulated lymphocyte proliferation (27.03% ± 0.92% vs. Model group 10.60% ± 4.78%, Conclusion: The multiherbal formula YHD confers substantial protection against CTX-induced immunosuppression. Its mechanisms are associated with the restoration of immune organ integrity, promotion of lymphocyte activity, and rebalancing of the cytokine profile. These findings provide a pharmacological basis for the traditional use of YHD and support its potential as an adjuvant therapy for managing chemotherapy-related immunosuppression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.