Evidence map›Paper›PMID 42382163›Full record

ArticleArthroplasty today2026

The Efficacy and Safety of Tranexamic Acid in Revision Total Knee and Total Hip Arthroplasty: A Systematic Review and Meta-Analysis.

Amir Human Hoveidaei, Reza Niakan, Amirhossein Salmannezhad, Alireza Pouramini, Ryan Palmer, Sagar Telang, Nathanael D Heckmann

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Article in Arthroplasty today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amir Human HoveidaeiRubin Institute for Advanced Orthopedics, Sinai Hospital of Baltimore, Baltimore, MD, USA.
Reza NiakanStudent Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Amirhossein SalmannezhadKerman Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Alireza PouraminiStudent Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran.
Ryan PalmerDepartment of Orthopaedic Surgery, Keck Medical Center of USC, Los Angeles, CA, USA.
Sagar TelangDepartment of Orthopaedic Surgery, Keck Medical Center of USC, Los Angeles, CA, USA.
Nathanael D HeckmannDepartment of Orthopaedic Surgery, Keck Medical Center of USC, Los Angeles, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This study evaluated 3 key aspects of tranexamic acid (TXA) use following revision total hip arthroplasty (rTHA) and revision total knee arthroplasty (rTKA): 1) its efficacy, including changes in hemoglobin, blood loss, blood transfusions, and red blood cell transfusions; 2) its safety, specifically venous thromboembolism including pulmonary embolism and deep vein thrombosis; and 3) the role of TXA administration, including the dose and route. Methods: A comprehensive search was conducted across PubMed, Scopus, Cochrane Cochrane Central Register of Controlled Trials, Embase, and Web of Science through 2024. Studies comparing TXA treatment to non-TXA treatment in patients undergoing rTHA or rTKA were included. Results: Our study included 27 studies with 10,248 patients (4700 in the TXA group and 5548 in the non-TXA group). A total of 25 studies were subjected to meta-analysis. Hemoglobin differences were significantly lower in TXA patients compared to non-TXA patients in both the rTHA (weighted mean difference [WMD] -0.79 g/dl, Conclusions: TXA was found to be effective and safe in both rTHA and rTKA, regardless of administration dose or route.

Indexed as

Blood lossBlood transfusionRevision arthroplastyTotal hip arthroplastyTotal knee arthroplastyTranexamic acid

Identifiers

PMID42382163
PMCPMC13314583

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.