ArticleOncoTargets and therapy2026
ELOVL6 Promotes the Proliferation and Migration of Oral Squamous Cell Carcinoma Cells Through Fatty Acid Remodelling and ROS Modulation in vitro.
Article in OncoTargets and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Elongase of very long-chain fatty acids 6 (ELOVL6), a key enzyme in long-chain fatty acid elongation, has been implicated in tumour progression, but its role in oral squamous cell carcinoma (OSCC) remains unclear. Methods: In vitro experiments were performed using OSCC cell lines with ELOVL6 knockdown or over-expression and assessed with CCK-8, scratch, transwell migration and invasion assays, lipidomic profiling, immunofluorescence, and quantitative PCR. Results: ELOVL6 knockdown (KD-ELOVL6) significantly reduced cell proliferation, migration, and invasion, whereas ELOVL6 over-expression (OE-ELOVL6) enhanced these malignant phenotypes. Lipidomic analysis revealed decreased palmitic acid and increased oleic acid and other long-chain fatty acids in OE-ELOVL6 cells. Similarly, fatty acid metabolism-related genes ( Conclusion:
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