ArticleFrontiers in neuroscience2026
Brain protein burden is related to intravoxel incoherent motion: PET-MR imaging study.
Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Dysfunction in brain protein clearance mechanisms is thought to contribute to many neurodegenerative diseases, yet non-invasive assessment of these mechanisms in humans remains challenging. This study is the first to examine whether intravoxel incoherent motion (IVIM) diffusion MRI metrics, measures of water diffusion and fluid dynamics, are associated with pathological protein accumulation and cognition in aging individuals, and hence whether they serve as a proxy for brain waste clearance function. Methods: We analyzed data from 94 participants ( Results: The model identified a subset of 25 key features that effectively predicted Aβ status, achieving a predictive accuracy of 80.0% on unseen data. Regions with important IVIM features aligned with previously identified Aβ-affected regions and showed significant correlations with Aβ burden (r = 0.53, Conclusion: IVIM-derived metrics (D, D*, and
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.