ArticleSmart molecules : open access2026
A general and green approach of pH-sensitive ZIF-67 for encapsulating active substances.
Article in Smart molecules : open access, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- ZIF-67 and Mn & Zn co-doped ZIF-67 as multifunctional therapeutic platforms: Antibacterial, antioxidant, and anticancer assessment in lung cancer cellsBiomaterials and biosystems · 2026Article
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7 authors.
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Abstract
Zeolitic imidazolate framework-67 (ZIF-67) has emerged as a promising carrier for active substances (AS) due to its biocompatibility and acid-triggered degradation behavior. Conventional loading strategies often involve multi-step post-synthetic modifications or one-pot processes employing toxic organic solvents. This study presents a facile one-pot synthesis method for encapsulating AS into ZIF-67 in deionized water within 2 h under ambient conditions. This method exhibits broad applicability, enabling effective encapsulation of both hydrophobic and hydrophilic molecules with molecular weights ranging from low to high, with loading efficiencies between 12.17% and 56.11%. While free compounds were released rapidly in a pH-independent manner, both CA@ZIF-67 and EGCG@ZIF-67 proved pH-responsive sustained release profiles, with their mechanisms best described by the first-order model and Fickian diffusion, respectively. Moreover, these composites demonstrated synergistic and pH-dependent antibacterial activity against
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