Evidence map›Paper›PMID 42382060›Full record

ArticleJournal of traditional and complementary medicine2026

Enhanced bone tissue regeneration via mesenchymal stem cells-laden Alginate/GelMa 3D-Bioprinted scaffold treated with

Fatemeh Jamshidi-Adegani, Sulaiman Al-Hashmi, Saeid Vakilian, Juhaina Al-Kindi, Fahad Al-Fahdi, Mohammed Al-Broumi, Abdullah Al-Hadhrami, Nasar Alwahaibi, Asem Shalaby, Simon Gibbons and 2 more

Abstract read
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In one paragraph

Article in Journal of traditional and complementary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fatemeh Jamshidi-AdeganiLaboratory for Stem Cell and Regenerative Medicine, Natural and Medical Sciences Research Center, University of Nizwa, P. O. Box: 33, 616, Nizwa, Oman.
Sulaiman Al-HashmiLaboratory for Stem Cell and Regenerative Medicine, Natural and Medical Sciences Research Center, University of Nizwa, P. O. Box: 33, 616, Nizwa, Oman.
Saeid VakilianLaboratory for Stem Cell and Regenerative Medicine, Natural and Medical Sciences Research Center, University of Nizwa, P. O. Box: 33, 616, Nizwa, Oman.
Juhaina Al-KindiLaboratory for Stem Cell and Regenerative Medicine, Natural and Medical Sciences Research Center, University of Nizwa, P. O. Box: 33, 616, Nizwa, Oman.
Fahad Al-FahdiLaboratory for Stem Cell and Regenerative Medicine, Natural and Medical Sciences Research Center, University of Nizwa, P. O. Box: 33, 616, Nizwa, Oman.
Mohammed Al-BroumiNatural and Medical Sciences Research Center, University of Nizwa, P. O. Box: 33, 616, Nizwa, Oman.
Abdullah Al-HadhramiLaboratory Animal Sciences House, University of Nizwa, P. O. Box: 33, 616, Nizwa, Oman.
Nasar AlwahaibiDepartment of Biomedical Science, College of Medicine & Health Sciences, Sultan Qaboos University, P. O. Box: 35, Alkoudh.123, Oman.
Asem ShalabyDepartment of Pathology, College of Medicine & Health Sciences, Sultan Qaboos University, P. O. Box: 35, Alkoudh.123, Oman.
Simon GibbonsNatural and Medical Sciences Research Center, University of Nizwa, P. O. Box: 33, 616, Nizwa, Oman.
Ahmed Al-HarrasiNatural and Medical Sciences Research Center, University of Nizwa, P. O. Box: 33, 616, Nizwa, Oman.
Wafa Al-RawahiApplied Chemistry Section, Department of Applied Sciences, University of Technology and Applied Sciences, Al Khuwair-33, Muscat, Oman.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and aim: Regeneration of critical-sized bone defects is challenging due to avascular necrosis, inflammation, and disrupted osteogenesis. This study explores the synergistic effects of Methods: Ethanolic extracts of stems (HTS), flowers (HTF), and a mixture (HTM) were obtained via Soxhlet extraction and subsequently characterized. Further investigations into their cytotoxicity, osteogenic and bone tissue regeneration potential were conducted, Results: Alongside GC-MS analysis, vitamin and elemental analyses of HTS, HTF, and HTM revealed varying concentrations of key elements essential for bone regeneration. All extracts exhibited moderate antioxidant activity, with more potency in the HTF group. Cytotoxicity assays indicated the lack of cytotoxic effects from HTS and HTF on MSCs. The calcium secretion and deposition on MSCs revealed the osteogenic potential of HTF and HTM. Gene and protein expression analyses indicated significant upregulation of osteogenic markers in HTF-treated MSCs. The integration of MSCs into a Alg/GelMa 3D-bioprinted scaffold enhanced their viability and proliferation, validating its biocompatibility. Additionally, HTF promoted calcium deposition and ALP activity in the MSC-laden 3D-bioprinted scaffold. Conclusion: This study underscores the significant role of the HTF in promoting osteogenesis, advocating for its incorporation into advanced tissue engineering strategies for bone regeneration.

Indexed as

BoneHaplophyllum tuberculatumOsteogenic differentiationStem cellsTissue engineering

Identifiers

PMID42382060
PMCPMC13316412

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.