Evidence map›Paper›PMID 42382046›Full record

ArticleThe journal of allergy and clinical immunology. Global2026

Fractional exhaled nitric oxide and blood eosinophils in relation to lung function, allergy and nasal polyps in asthma.

Reshed Abohalaka, Lauri Lehtimäki, Selin Ercan, Daniil Lisik, Saliha Selin Özuygur Ermis, Pinja Ilmarinen, Teet Pullerits, Helena Backman, Madeleine Rådinger, Bright I Nwaru and 1 more

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In one paragraph

Article in The journal of allergy and clinical immunology. Global, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Reshed AbohalakaKrefting Research Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Lauri LehtimäkiAllergy Centre, Tampere University Hospital, Tampere, Finland.
Selin ErcanKrefting Research Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Daniil LisikKrefting Research Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Saliha Selin Özuygur ErmisKrefting Research Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Pinja IlmarinenFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Teet PulleritsKrefting Research Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Helena BackmanDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Madeleine RådingerKrefting Research Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Bright I NwaruKrefting Research Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Hannu KankaanrantaKrefting Research Centre, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Type 2 inflammation plays a central role in asthma, but blood eosinophil count (BEC) and fractional exhaled nitric oxide (Feno) levels may reflect different type 2 pathways. Their associations with different asthma characteristics in unselected populations remain unclear. Objectives: To examine how BEC and Feno, independently and synergistically, are related to lung function, allergy, and nasal polyps in a population-based asthma cohort. Methods: Data were analyzed from 1567 participants with physician-diagnosed asthma in the West Sweden Asthma Study. Lung function, bronchodilator responsiveness, and presence of allergy and nasal polyps were evaluated across categories of BEC and Feno labeled as low, medium, or high using various cutoffs. Associations were assessed using linear and logistic regression models in participants who were inhaled corticosteroid (ICS)-naive and ICS-treated separately. Results: Of participants, 49% (n = 767) were on ICS treatment at the time of examination. Among those who were ICS-treated, BEC, independently of Feno, was associated with reduced FEV Conclusion: BEC and Feno reflect distinct yet complementary aspects of type 2 inflammation in asthma. These findings support the joint use of BEC and Feno for obstructive airway diseases phenotyping.

Indexed as

allergic sensitizationallergyasthmaBlood eosinophil countFenofractional exhaled nitric oxidelung function

Identifiers

PMID42382046
PMCPMC13315671

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.