ArticleBlood neoplasia2026
Genomic features of clonal hematopoiesis-associated genes in primary and CAR T-cell-related secondary T-cell malignancies.
Article in Blood neoplasia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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9 authors.
Funding
Abstract
Secondary T-cell leukemias and lymphomas (TCLs) manifesting after chimeric antigen receptor (CAR) T-cell therapy represent an emerging concern, but their pathogenesis remains poorly understood. Risk factors are multifactorial and potentially include previous exposure to anticancer treatments, insertional mutagenesis, latent oncogenic mutations, and clonal hematopoiesis (CH). In this study, the molecular features of CAR T-cell-associated secondary TCLs are analyzed and contrasted with those of primary TCLs. Our study also examines the role of CH and its interplay with somatic mutations that are associated with TCL pathogenesis, with implications for patient risk stratification, monitoring, and treatment.
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