ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Variable Aβ tracer uptake in hyperostosis frontalis interna: implications for brain Aβ PET/CT interpretation.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
introductionHyperostosis frontalis interna (HFI) is a relatively common incidental finding on head computed tomography (CT). We report two patients with HFI identified on amyloid-beta (Aβ) positron emission tomography (PET)/CT who demonstrated distinct patterns of tracer uptake within the affected calvarium.
methodsBoth patients underwent
resultsPatient 1 was an 85-year-old woman with amnestic mild cognitive impairment whose DISCUSSION: Off-target tracer retention within the calvarium may represent a source of visual and quantitative misinterpretation in Aβ and tau PET scans in patients with HFI, particularly older women. Careful visual inspection and adjustment of automated quantification masks are essential to avoid inaccurate Centiloid and standardized uptake value ratio measurements.
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