ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Anti-amyloid therapy eligibility in a longitudinal brain-donor cohort with
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionAnti-amyloid therapies (AATs) for Alzheimer's disease (AD) demonstrate modest benefit in trials, but real-world eligibility remains uncertain. Requirements including biomarker confirmation and safety exclusions may limit access.
methodsUsing the Brains for Dementia Research cohort, we linked longitudinal cognitive data with
resultsOf 1230 participants, 945 had sufficient data; 232 had early, pathology-confirmed AD. Vascular pathology excluded 70.7%, anticoagulant use 19.1%, and DISCUSSION: Using a conservative pathology-anchored framework, only a small proportion of this older brain-donor cohort met trial-like eligibility criteria.
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