Evidence map›Paper›PMID 42381969›Full record

ArticleBioactive materials2026

Reprogramming macrophage mechanosensation via TRPV4 modulating mechano-immunotherapy controls fibrotic encapsulation of biomaterial implants.

Xueying Xu, Alex H P Chan, Yunfei Hu, Kieran Lau, Billie Pardavi, Ian L Chin, Matt Crago, Sina Naficy, Angus J Grant, Khoon S Lim and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xueying XuSchool of Medical Sciences, Faculty of Health and Medicine, University of Sydney, NSW, 2006, Australia.
Alex H P ChanSchool of Medical Sciences, Faculty of Health and Medicine, University of Sydney, NSW, 2006, Australia.
Yunfei HuSchool of Medical Sciences, Faculty of Health and Medicine, University of Sydney, NSW, 2006, Australia.
Kieran LauSchool of Medical Sciences, Faculty of Health and Medicine, University of Sydney, NSW, 2006, Australia.
Billie PardaviSchool of Medical Sciences, Faculty of Health and Medicine, University of Sydney, NSW, 2006, Australia.
Ian L ChinSchool of Medical Sciences, Faculty of Health and Medicine, University of Sydney, NSW, 2006, Australia.
Matt CragoSchool of Chemical Engineering, Faculty of Engineering, University of Sydney, NSW, 2006, Australia.
Sina NaficySchool of Chemical Engineering, Faculty of Engineering, University of Sydney, NSW, 2006, Australia.
Angus J GrantSchool of Medical Sciences, Faculty of Health and Medicine, University of Sydney, NSW, 2006, Australia.
Khoon S LimSchool of Medical Sciences, Faculty of Health and Medicine, University of Sydney, NSW, 2006, Australia.
Steven G WiseSchool of Medical Sciences, Faculty of Health and Medicine, University of Sydney, NSW, 2006, Australia.
Lining Arnold JuCharles Perkins Centre, University of Sydney, NSW, 2006, Australia.
Richard P TanSchool of Medical Sciences, Faculty of Health and Medicine, University of Sydney, NSW, 2006, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Modulating how macrophages sense mechanical cues offers a novel strategy to control fibrosis around implanted biomaterials. We term this approach 'mechano-immunotherapy', which involves the desensitization of immune mechanosensory pathways to control the host response. Here, we use RN-1734 (RN), a model small molecule to demonstrate the proof-of-concept that pharmacologically disrupting macrophage mechanosensation can mitigate fibrosis.

Indexed as

BiomaterialsForeign body responseMechanobiologyMechanosensationTRPV4

Identifiers

PMID42381969
PMCPMC13316282

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.